TREATMENT OF CHRONIC HEPATITIS C Standard Therapy Hoofnagle JH, Mullen KD, Jones DB, et al. Treatment of chronic non-A, non-B hepatitis with
recombinant human alpha interferon: A preliminary report. New Engl J Med 1986; 315:1575-1578. Davis GL, Balart LA, Schiff ER, et al. Treatment of chronic hepatitis C with recombinant
interferon alpha: A multicenter randomized, controlled trial. New Engl J Med 1989; 321:1501-1506. Marcellin P, Boyer N, Giostra, et al. Recombinant human alpha- interferon in patients
with chronic non A non B hepatitis: a multicenter randomized controlled trial from France. Hepatology 1991; 13:393-397. Causse x, Godinot H, Ouzan D, et al. Comparison of 1 or 3 MU of
interferon alfa-2b and placebo in patients with chronic non-A non-B hepatitis. Gastroenterology 1991; 101:497-502. TinŽ F, Margin S, Craxi A, Pagliaro L. Interferon for non-A, non- B
chronic Hepatitis: a meta-analysis of randomized clinical trials. J Hepatol 1991; 13:192-199. Alternative regimens: Higher dose, Longer duration Beloqui O, Prieto J,
Suarez M, Gil B, Qian CH, Garcia N, Civeira MP. N-acetyl cysteine enhances the response to interferon-alpha in chronic hepatitis C: a pilot study. J Interferon Res 1993; 13:279-282.
Kakumu S, Yoshioka K, Wakita T, Ishikawa T, Takayanagi M, Higashi Y. A pilot study of ribavirin and interferon beta for the treatment of chronic hepatitis C. Gastroenterology 1993; 105:507-
512. Liaw YF, Sheen IS, Lin SM, Chen TJ, Chu CM. Effects of prednisolone pretreatment in interferon alfa therapy for patients with chronic non-A, non-B (C) hepatitis. Liver 1993;
13:46-50. Alternatives to Interferon Camps J, Garcia N, Riezu-Boj JI, Civiera MP, Prieto J. Ribavirin in the treatment of chronic hepatitis C unresponsive to alfa
interferon. J Hepatol 1993; 19:408-412. Bodenheimer HC, Lindsay K, Davis GL, et al. Ribavirin treatment of chronic hepatitis C. Hepatology 1994; 20:(abstract in press).
SPECIAL PATIENT GROUPS Decompensated Cirrhosis Dimopoulou M, Fafoutis K, Basiliou K, Ketikoglou J, Karvountzis G. Interferon alfa-2a for decompensated liver disease caused by wither
chronic hepatitis B or C: preliminary results of a pilot study. Gut 1993; 34 (suppl 2):S104-105. HIV infected patients Eyster
ME, Diamondstone LS, Lien JM, Ehmann WC, Quan S, Goedert JJ. The natural history of hepatitis C virus infection in multitransfused hemophiliacs: Effects of coinfection with human
immunodeficiency virus. Acquir Immune Defic Syndr 1993; 6:602. Eyster ME, Fried MW, DiBisceglie AM, Goedert JJ. Increasing HCV RNA levels in hemophiliacs: Relationship to HIV infection
and liver disease. Blood 1994; (in press). Boyer N, Marcellin P. Degott C, Degos F, Saimot AG, Erlinger S, Benhamou JP. Recombinant interferon-alpha for chronic hepatitis C in patients
positive for antibody to human immunodeficiency virus. J Infect Dis 1992; 165:723-726. Hemophiliacs Makis M, Preston FR, Triger DR, Underwood JC, Westlake L, Adelman MI.
A randomized controlled trial of recombinant interferon-alpha in chronic hepatitis C in hemophiliacs. Blood 1991; 78:1672-1677. Transplant Recipients Lim HL, Lau GK,
Davis GL, Dolson DJ, Lau JYN. Cholestatic hepatitis leading to hepatic failure in a patients with organ- transmitted hepatitis C virus infection. Gastroenterology 1994; 106:248-251.
Ferrel LD, Wright TL, Roberts J, Ascher N, Lake J. Hepatitis C viral infection in liver transplant recipients. Hepatology 1992; 16:865-876. Wright HI, Gavaler JS, Van Thiel DH. Preliminary
experience with alpha-2b interferon therapy of viral hepatitis in liver allograft recipients. Transplantation 1992; 53:121-124. Asymptomatic Carriers Naito M, Hayashi
N, Hagiwara H, Hiram N, Kasahara A, Fusamato H, Kamada T. Serum hepatitis C virus RNA quantity and histological features of hepatitis C virus carriers with persistently normal ALT levels.
Hepatology 1994; 19:871-875. Extrahepatic Disease Lunel F, Musset L, Cacoub P, et al. Cryoglobulinemia in chronic liver diseases: role of hepatitis C virus and liver damage.
Gastroenterology 1994; 106:1291-1300. TREATMENT OF ACUTE HEPATITIS C Viladomiu L, Genesca J, Estaban JI, et al. Interferon alpha in acute posttransfusion hepatitis C:
a randomized controlled trial. Hepatology 1992; 15:767-769. Omata M, Yokosuka O, Takano S et al. Resolution of acute hepatitis C after therapy with natural beta interferon. Lancet 1991;
338:914-915. Lampertico P, Rumi M, Romeo R, Craxi A, Soffrededini R, Biassoni D, Colombo M. A multicenter randomized controlled trial of recombinant interferon alpha-2b in patients with
acute transfusion- associated hepatitis C. Hepatology 1994; 19:19-22. Tassopoulos NC, Koutelou MG, Papatheodoridis G, et al. Recombinant human interferon alfa-2b treatment for acute
non-A, non-B hepatitis. Gut 1993; 34:S130-132.
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